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Neladenoson dalanate hydrochloride

CAS No. 1239235-25-6

Neladenoson dalanate hydrochloride( BAY 10-67197 )

Catalog No. M10960 CAS No. 1239235-25-6

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Neladenoson dalanate hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.
  • Description
    Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.Heart Failure Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BAY 10-67197
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1239235-25-6
  • Formula Weight
    752.73
  • Molecular Formula
    C35H35Cl2N7O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@@H](C(OCCOC1=CC=C(C2=C(C#N)C(SCC3=CSC(C4=CC=C(Cl)C=C4)=N3)=NC(N5CCCC5)=C2C#N)C=C1)=O)NC([C@H](C)N)=O.[H]Cl
  • Chemical Name
    2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol- 4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin- 4-yl]phenoxy}ethyl L-alanyl-L-alaninate hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meibom D, et al. ChemMedChem. 2017 May 22;12(10):728-737. 2. Voors AA, et al. J Clin Pharmacol. 2017 Apr;57(4):440-451.
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